Nhà Sinh Học Trẻ

Hôm nay học Bionanotechnology, được Prof. giới thiệu bài này hay quá nên muốn giới thiệu lại với diễn đàn.
Mọi người đọc thử phần News trên Nature tóm tắt nha:
"...Rothemund has invented what he calls 'DNA origami', a method for building just about any two-dimensional pattern out of DNA molecules. His portfolio includes smiley faces, triangles, snowflakes and flowers.
Each item takes a month to plan and a few hours to make. All are made of a standard, single strand of viral DNA folded back and forth over rows of double helices in a template shape. The shape is maintained by DNA 'staples' - specially designed short strands - that stop the viral strand from unravelling.

Round the bend

First, Rothemund draws the shape on a piece of graph paper, and fills it with a single line. He describes the twists and turns of the line to his computer, which determines how many staples are needed and their chemical composition.
Then you send off for the DNA, says Rothemund. When it arrives, mix it together with a little salt, heat to near boiling and allow it to cool slowly. The DNA self-assembles into the required shape.
..."

_________________
many roads to take: some to joys, some to heartache...

SV sưu tầm được vài hình màu trong bài báo

Công trình đầy thú vị và khá ... xa xỉ này đã có những bước phát triển tiếp tục. Các nhà khoa học vừa thành công "lắp ghép" những chiếc hộp từ DNA với nắp có thề kiểm soát đóng mở (<-- ứng dụng đầu tiên được kể tới hẳn là drug delivery - tuy đường còn xa nhưng cũng thật là đáng khích lệ)
Bài báo khoa học:
Self-assembly of a nanoscale DNA box with a controllable lid
Nature 459, 73-76 (7 May 2009)
http://www.nature.com/nature/journal/v4 ... 07971.html
Abstract
"...Here we extend the DNA origami method into three dimensions by creating an addressable DNA box 42 x 36 x 36 nm3 in size that can be opened in the presence of externally supplied DNA 'keys'. We thoroughly characterize the structure of this DNA box using cryogenic transmission electron microscopy, small-angle X-ray scattering and atomic force microscopy, and use fluorescence resonance energy transfer to optically monitor the opening of the lid. Controlled access to the interior compartment of this DNA nanocontainer could yield several interesting applications, for example as a logic sensor for multiple-sequence signals or for the controlled release of nanocargos."

_________________
on my way ...!